Domain

ALIX V-shaped domain (IPR025304)

Short name: ALIX_V_dom

Domain relationships

None.

Description

The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding. In ALIX, a component of the ESCRT pathway, this domain is central between an N-terminal Bro1 domain (PF03097) and a C-terminal proline-rich domain. The ALIX central domain is formed by two three-helix bundles disposed in a V shape [PMID: 17350572, PMID: 17277784]. Retroviruses thus used this domain to hijack the ESCRT system of the cell [PMID: 18066081].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam