Domain

ALIX V-shaped domain (IPR025304)

Short name: ALIX_V_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding. In ALIX, a component of the ESCRT pathway, this domain is central between an N-terminal Bro1 domain (PF03097) and a C-terminal proline-rich domain. The ALIX central domain is formed by two three-helix bundles disposed in a V shape [PMID: 17350572, PMID: 17277784]. Retroviruses thus used this domain to hijack the ESCRT system of the cell [PMID: 18066081].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam