Type I toxin-antitoxin system, toxin Ldr (IPR025253)

Short name: Toxin_Ldr

Overlapping homologous superfamilies


Family relationships



This family includes the Ldr (long direct repeat) toxins. In Escherichia coli there are four Ldr toxins, LdrA, LdrB, LdrC and LdrD. These toxins inhibit cell growth, decrease cell viability and cause nucleoid condensation. They are part of the type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA. For example, LdrD expression is inhibited by the antisense RNA RdlD, which functions as an antitoxin [PMID: 12123448].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.