Cell cycle and apoptosis regulator protein (IPR025224)

Short name: CCAR1/CCAR2

Overlapping homologous superfamilies


Family relationships


Cell division cycle and apoptosis regulator protein 1 (CCAR1) associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery. CCAR1 also functions as a p53 coactivator and regulates expression of key proliferation-inducing genes [PMID: 18722177].

Cell cycle and apoptosis regulator protein 2 (CCAR2, also known as DBC-1) regulates biological processes such as transcription, heterochromatin formation, metabolism, mRNA splicing, apoptosis, and cell proliferation [PMID: 23352644]. It is a core component of the DBIRD complex, which affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions [PMID: 23352644]. It binds to SIRT1 and is a negative regulator of SIRT1 [PMID: 18235501]. DBC-1 has been implicated in tumorigenesis [PMID: 19657230].

This entry also includes protein SHORT ROOT IN SALT MEDIUM 1 from Arabidopsis. It regulates the transcription of several genes involved in the detoxification of reactive oxygen species generated by salt stress and the SOS1 gene that encodes a plasma membrane Na(+)/H(+) antiporter essential for salt tolerance [PMID: 24009530].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.