Centromere protein U (IPR025214)

Short name: CENP-U

Overlapping homologous superfamilies


Family relationships



The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. All active centromeres are characterised by the presence of long arrays of nucleosomes in which CENP-A replaces histone H3. CENP-A assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [PMID: 16622419].

CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.