Toxin TisB, type I toxin-antitoxin system (IPR025211)

Short name: TisB_toxin

Overlapping homologous superfamilies


Family relationships



TisB (toxicity-induced by SOS B) is an SOS-induced toxic peptide and is part of the type I toxin-antitoxin system, in which the antitoxin is a non-coding RNA. It is a hydrophobic membrane-spanning protein that inhibits cell growth [PMID: 18761622]. Its expression is inhibited by the antisense RNA IstR-1 [PMID: 15620655]. TisB appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics [PMID: 18761622, PMID: 23062338, PMID: 22728134].

GO terms

Biological Process

GO:0009432 SOS response
GO:0022611 dormancy process

Molecular Function

GO:0005253 anion channel activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.