Domain

AATF leucine zipper-containing domain (IPR025160)

Short name: AATF

Domain relationships

None.

Description

This leucine zipper-containing domain is found in apoptosis antagonizing transcription factor (AATF, also known as Che-1) and related proteins. AATF may function as a general inhibitor of the histone deacetylase HDAC1 [PMID: 12450794]. AATF has been shown to inhibit the abberant production of the amyloid beta peptide 1-42 by direct interaction with Par4 [PMID: 14627703]. This interaction occurs via the leucine zipper.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam