Maelstrom domain (IPR024970)

Short name: Maelstrom

Overlapping homologous superfamilies


Domain relationships



Maelstrom is a germ-plasm component protein that is involved in the piRNA pathway, though its precise function is not known. This protein contains a novel domain, known as the Maelstrom domain, which adopts the RNaseH fold. Maelstrom is essential for Piwi-mediated silencing and acts downstream of or in parallel to H3K9me3 in Drosophila [PMID: 23159368].

GO terms

Biological Process

GO:0060964 regulation of gene silencing by miRNA

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.