CTLH/CRA C-terminal to LisH motif domain (IPR024964)

Short name: CTLH/CRA

Overlapping homologous superfamilies


Domain relationships



RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. The RanBPM protein contains multiple conserved domains that provide potential protein-protein interaction sites [PMID: 22094242]. This entry represents a domain at the C terminus of RanBPM containing the CT11-RanBPM (CRA) motif. The CRA motif was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined [PMID: 15381419]. The region comprising this domain contains the CTLH and CRA domains annotated by SMART; however, these may be a single domain, and is referred to as a C-terminal to LisH motif [PMID: 11734546].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.