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Overview
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Structures
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Cross-references
Domain
SSRP1 domain (IPR024954)
Short name: SSRP1_dom
Overlapping homologous superfamilies
- SSRP1 domain superfamily (IPR038167)
Domain relationships
None.
Description
This domain is found in structure-specific recognition protein SSRP1 (POB3 in yeast) and related proteins, which are components of the FACT complex - a general chromatin factor that acts to reorganise nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair [PMID: 14585989, PMID: 10924459]. During transcription elongation the FACT complex acts as a histone chaperone that both destabilises and restores nucleosomal structure [PMID: 9489704, PMID: 12934006].
This domain has a Pleckstrin homology fold.
Contributing signatures
Signatures from InterPro member databases are used to construct an entry.
Pfam
- PF03531 (SSrecog)