InterPro

This domain is found in structure-specific recognition protein SSRP1 (POB3 in yeast) and related proteins, which are components of the FACT complex - a general chromatin factor that acts to reorganise nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair [PMID: 14585989, PMID: 10924459]. During transcription elongation the FACT complex acts as a histone chaperone that both destabilises and restores nucleosomal structure [PMID: 9489704, PMID: 12934006].

This domain has a Pleckstrin homology fold.