Enhancer of polycomb protein (IPR024943)

Short name: Enhancer_polycomb

Overlapping homologous superfamilies


Family relationships



The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals [PMID: 9735366]. The homologous yeast protein, known as enhancer of polycomb-like protein 1 (Epl1), is a subunit of the NuA4 histone acetyltransferase (HAT) complex, which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A [PMID: 12782659]. Epl1 also found in a novel highly active smaller complex named Piccolo NuA4 (picNuA4), which strongly prefers chromatin over free histones as substrate [PMID: 12782659]. The NuA4 HAT complex is highly conserved in eukaryotes, and it plays primary roles in transcription, cellular response to DNA damage, and cell cycle control [PMID: 14966270].

This entry represents all eukaryotic enhancer of polycomb proteins, including enhancer of polycomb-like proteins.

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0035267 NuA4 histone acetyltransferase complex
GO:0032777 Piccolo NuA4 histone acetyltransferase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.