Acid phosphatase, type 5 (IPR024927)

Short name: Acid_Pase_5

Overlapping homologous superfamilies

Family relationships



Acid phosphatase 5 (ACP5) removes the mannose 6-phosphate recognition marker from lysosomal proteins. The exact site of dephosphorylation is not clear. Evidence suggests dephosphorylation may take place in a prelysosomal compartment as well as in the lysosome [PMID: 18940929]. ACP5 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues [PMID: 15993892].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003993 acid phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.