Acid phosphatase, type 5 (IPR024927)

Short name: Acid_Pase_5

Family relationships



This family is one of several unrelated acid phosphatase families found in humans and other mammals; it includes proteins from plants and a few prokaryotes. Because of variations in post-translational processing and tissue expression, it was thought that mammals contained a multigene family of purple acid phosphatases. However, only one gene produces the various forms [PMID: 8463220], including purple acid phosphatases from spleen (and other tissues), tartrate-resistant acid phosphatase from macrophage lysosomes, and uteroferrin, which has a role in delivering iron to the in utero fetus. In humans, this normally minor intracellular acid phosphatase can become dominant in certain pathological states (Gaucher's and Hodgkin's diseases, and the hairy cell, B-cell, and T-cell leukemias).

The purple phosphatases contain a dinuclear iron active site responsible for the purple color. Despite limited sequence identity, the protein fold resembles that of the catalytic domain of plant purple acid phosphatase and other serine/threonine-protein phosphatases that also contain a metallophosphoesterase domain (IPR004843) [PMID: 10388567].

For additional information please see [PMID: 8127141, PMID: 2394317].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003993 acid phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.