Cysteinyl-tRNA synthetase/mycothiol ligase (IPR024909)

Short name: Cys-tRNA/MSH_ligase

Overlapping homologous superfamilies

Family relationships


This entry represents a subgroup of the class-I aminoacyl-tRNA synthetase family. It includes cysteinyl-tRNA synthetase and the related enzyme mycothiol ligase [PMID: 12033919].

Cysteine-tRNA ligase (also known as Cysteinyl-tRNA synthetase) (EC: is an alpha monomer and belongs to class Ia [PMID: 1992490]. It is highly specific despite not possessing the amino acid editing activity characteristic of many other tRNA ligases [PMID: 12032090].

Mycothiol ligase, also known as L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis [PMID: 16674910].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.