Ornithine carbamoyltransferase (IPR024904)

Short name: OTCase_ArgI

Overlapping homologous superfamilies

Family relationships


Ornithine carbamoyltransferases catalyse the production of citrulline from carbamoyl-phosphate and ornithine [PMID: 2121620]. This reaction is part of the arginine biosynthetic pathway, and in some organisms the reaction is also part of the arginine deaminase pathway [PMID: 3109911]. In most prokaryotes, and some lower eukaryotes, the enzyme is found in the cytoplasm, but in higher eukaryotes, such as mammals, the enzyme is found in the mitochondrial matrix and functions as part of the urea cycle. In most organisms analysed to date, the enzyme has been shown to consist of a trimer of identical or nonidentical subunits [PMID: 3038540]. Extensive similarity has been found within the ornithine carbamoyltransferase family, some of the conserved areas being important in catalysis [PMID: 3020372]. The C-terminal region of these enzymes contains a highly conserved Cys residue (in a His-Cys-Lys-Pro motif) implicated in ornithine binding [PMID: 3038540].

GO terms

Biological Process

GO:0006591 ornithine metabolic process

Molecular Function

GO:0004585 ornithine carbamoyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.