Bone marrow stromal antigen 2 (IPR024886)

Short name: BST2

Overlapping homologous superfamilies


Family relationships



Bone marrow stromal antigen 2, also known as tetherin, is an antiretroviral defence protein, that blocks release of enveloped virus from the cell surface [PMID: 18200009, PMID: 20686043, PMID: 20940320]. Bst2/tetherin contains two membrane anchors which are employed to retain some enveloped viruses, including HIV-1, tethered to the plasma membrane in the absence of virus encoded antagonists [PMID: 20399176]. Its expression is induced by interferon-alpha [PMID: 19032371] and was originally linked to B cell development [PMID: 7607676].

GO terms

Biological Process

GO:0051607 defense response to virus

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.