N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D (IPR024884)

Short name: NAPE-PLD

Overlapping homologous superfamilies

Family relationships



N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D (NAPE-PLD) hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) [PMID: 15878693]. It is responsible for the generation of the NAE anandamide, the ligand of cannabinoid and vanilloid receptors [PMID: 14634025]. Although predominantly bacterial, a mitochondrial form exists [PMID: 15878693]. NAPE-PLD belongs to the metallo-beta-lactamase family [PMID: 16527816].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.