T-cell immunomodulatory protein (IPR024881)

Short name: Tip

Overlapping homologous superfamilies


Family relationships



T-cell immunomodulatory protein (Tip) is a modulator of T-cell function. It has a protective effect in graft versus host disease model [PMID: 12598909] and may protect the parasite against attack by the host immune system by immunomodulation [PMID: 12833085].

This entry also includes LINKIN from C. elegans. LINKIN is a transmembrane protein required for maintaining tissue integrity through cell adhesion and apical polarization. It is suggested to be an adhesion molecule that uses its extracellular domain to bind molecules on the surface of neighbouring cells and its intracellular domain to regulate microtubule dynamics [PMID: 25437307].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.