Short name: Dact1
Overlapping homologous superfamilies
- Dapper (IPR024843)
- Dact1 (IPR024848)
Dact (dapper) proteins were identified through binding to dishevelled, a cytoplasmic protein central to Wnt signaling. The different dact proteins seem to have distinct signaling and developmental roles. In Zebrafish, dact1 but not dact2 is required to enhance Wnt/beta-catenin activity, while functional interaction with Wnt/Ca2+-PCP signaling has been described for dact2, but not dact1 [PMID: 15539487]. Data from other vertebrates seems to be consistent with a distinct signaling and developmental role for dact1, dact2 and dact3 [PMID: 16881060].
This entry represents dact1. Dact1 is the orthologue of a protein known in Xenopus as dapper or frodo [PMID: 15870912].
- PTHR15919:SF12 (PTHR15919:SF12)