Family

Janus kinase and microtubule-interacting protein (IPR024836)

Short name: JAKMIP

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Janus kinase and microtubule interacting proteins (JAKMIPs) are predominantly expressed in neural tissues and lymphoid organs. Three family members have been identified, termed JAKMIP1-3. They contain an N-terminal region that targets the protein to microtubule polymers and a C-terminal region that is able to associate with Janus kinase (Jak) family members, such as Tyk2 or Jak1 [PMID: 15277531]. The proteins may have a role in Jak signalling and regulation of microtubule cytoskeleton rearrangements.

JAKMIP1 has also been shown to interact with GABA(B) receptor R1 subunits [PMID: 14718537], and may be involved in microtubule-dependent transport of the GABA-B receptor [PMID: 17532644].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019900 kinase binding
GO:0008017 microtubule binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER