Family

Janus kinase and microtubule-interacting protein (IPR024836)

Short name: JAKMIP

Family relationships

None.

Description

Janus kinase and microtubule interacting proteins (JAKMIPs) are predominantly expressed in neural tissues and lymphoid organs. Three family members have been identified, termed JAKMIP1-3. They contain an N-terminal region that targets the protein to microtubule polymers and a C-terminal region that is able to associate with Janus kinase (Jak) family members, such as Tyk2 or Jak1 [PMID: 15277531]. The proteins may have a role in Jak signalling and regulation of microtubule cytoskeleton rearrangements.

JAKMIP1 has also been shown to interact with GABA(B) receptor R1 subunits [PMID: 14718537], and may be involved in microtubule-dependent transport of the GABA-B receptor [PMID: 17532644].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019900 kinase binding
GO:0008017 microtubule binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER