Glucocorticoid modulatory element-binding protein 1/2 (IPR024830)

Short name: GMEB1/2

Overlapping homologous superfamilies


Family relationships



Glucocorticoid modulatory element-binding (GMEB) proteins 1 and 2 are homologous sequences that form a heteromeric complex that binds to glucocorticoid modulatory elements and increases sensitivity to low concentrations of glucocorticoids [PMID: 10894151, PMID: 10386584]. The GMEB1/2 complex is also an essential auxiliary factor for the replication of parvoviruses, critically regulating the viral nickase during infection [PMID: 10523663]. GMEB1 has been shown to inhibit caspase, preventing hypoxia- and oxidative stress-induced neuronal apoptosis [PMID: 18455874].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003713 transcription coactivator activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.