Radiation-inducible immediate-early gene IEX-1 (IPR024829)

Short name: IEX-1

Overlapping homologous superfamilies


Family relationships



Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene. The protein is involved in cell proliferation and survival, including the protection of cells from TNF-induced apoptosis [PMID: 9703517]. It is rapidly induced by growth factors, viral infections or chemical carcinogens [PMID: 12510147].

IEX-1 has a dual role in extracellular signal-regulated kinase (ERK) signalling. Upon phosphorylation by ERK, IEX-1 acquires the ability to inhibit cell death induced by various stimuli. In turn, by binding to active ERK, IEX-1 potentiates ERK activation in response to various growth factors [PMID: 16456541, PMID: 12356731].

GO terms

Biological Process

GO:0043066 negative regulation of apoptotic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.