Pathways & interactions
Short name: Uroplakin-3a
Overlapping homologous superfamilies
- Uroplakin-3 (IPR024831)
- Uroplakin-3a (IPR024825)
Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet [PMID: 27729990, PMID: 17183244]. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier [PMID: 7760330]. Uroplakins are also believed to play a role during urinary tract morphogenesis [PMID: 19340092, PMID: 17183244].
- PTHR15446:SF17 (PTHR15446:SF17)