Growth arrest and DNA damage-inducible protein GADD45 (IPR024824)

Short name: GADD45

Overlapping homologous superfamilies

Family relationships



The growth arrest and DNA damage GADD45 proteins, which include GADD45A, GADD45B , and GADD45G, are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation [PMID: 1482047, PMID: 11960329, PMID: 7973727]. GADD45 proteins interact with a number of other proteins implicated in stress responses, including PCNA, p21, Cdc2/CyclinB1, MEKK4, and p38 kinase. GADD45 stimulates DNA excision repair in vitro and inhibits the entry of cells into S phase during the cell cycle.

GO terms

Biological Process

GO:0051726 regulation of cell cycle

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.