Domain

T4 endonuclease V (IPR024796)

Short name: T4_endonuc_V

Domain relationships

None.

Description

Pyrimidine dimer DNA glycosylases are enzymes responsible for initiating the base excision repair pathway, excising pyrimidine dimers by hydrolysis of the glycosylic bond of the 5' pyrimidine, followed by the intra-pyrimidine phosphodiester bond [PMID: 11148051]. One such enzyme is T4 endonuclease V, an enzyme responsible for the first step of a pyrimidine-dimer-specific excision-repair pathway [PMID: 2067549]. Bacteriophage T4 that are deficient in these enzymes are extremely sensitive to UV.

The crystal structure of bacteriophage T4 endonuclease V reveals an enzyme composed of a single compact domain classified as an all-alpha structure [PMID: 7783199].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D