Anaphase-promoting complex subunit 4 (IPR024789)
Short name: APC4
Overlapping homologous superfamilies
- Anaphase-promoting complex subunit 4 (IPR024789)
- Anaphase-promoting complex subunit 4, metazoa (IPR017169)
The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome.
This family represents the anaphase-promoting complex subunit 4 (APC4). This entry also includes APC4 homologue, EMB-30, from Caenorhabditis elegans [PMID: 10749938].
- PTHR13260 (PTHR13260)