Domain

Transducer of regulated CREB activity, C-terminal (IPR024785)

Short name: TORC_C

Domain relationships

None.

Description

This entry represents the C-terminal domain of TORC proteins. TORC (transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-dependent transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [PMID: 14536081]. The C-terminal domain is negatively charged, resembling transcription activation domains, and experimental studies indicate that it may play a role in activation of transcription [PMID: 14506290].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam