Domain

Transducer of regulated CREB activity, N-terminal (IPR024783)

Short name: TORC_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of TORC proteins. TORC (transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-dependent transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [PMID: 14536081]. The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS) [PMID: 14506290]. The coiled-coil structure interacts with the bZIP domain of CREB [PMID: 14536081]. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions [PMID: 17565599]. In addition to CREB-binding, the N-terminal domain plays a role in the tetramer formation of TORCs [PMID: 14536081], but the physiological function of the multimeric complex has not been clarified yet.

GO terms

Biological Process

GO:0051289 protein homotetramerization

Molecular Function

GO:0008140 cAMP response element binding protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam