2OGFeDO, oxygenase domain (IPR024779)

Short name: 2OGFeDO_noxygenase_dom

Overlapping homologous superfamilies


Domain relationships



This entry represents the catalytic domain from nucleic-acid modifying members of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily [PMID: 19411852]. These proteins catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids [PMID: 20215442], and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC) [PMID: 19372391], or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) [PMID: 21817016]. Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers [PMID: 21057493]. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions [PMID: 19411852].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.