Pathways & interactions
Pleckstrin homology domain, Mcp5-type (IPR024774)
Short name: PH_dom-Mcp5-type
Overlapping homologous superfamilies
- Pleckstrin homology domain (IPR001849)
- Pleckstrin homology domain, Mcp5-type (IPR024774)
This pleckstrin homology domain is found in eukaryotic proteins, including Mcp5, a fungal protein that anchors dynein at the cell cortex during the horsetail phase (prophase I) of meiosis. During prophase I of fission yeast all the telomeres become bundled at the spindle pole body and subsequently the nucleus undergoes a dynamic oscillation, resulting in elongated nuclear morphology known as "horsetail" nucleus. The pleckstrin homology domain is necessary for the cortical localisation of the Mcp5 protein during meiosis [PMID: 16585273].
- PF12814 (Mcp5_PH)