Domain

Pleckstrin homology domain, Mcp5-type (IPR024774)

Short name: PH_dom-Mcp5-type

Overlapping homologous superfamilies

None.

Domain relationships

Description

This pleckstrin homology domain is found in eukaryotic proteins, including Mcp5, a fungal protein that anchors dynein at the cell cortex during the horsetail phase (prophase I) of meiosis. During prophase I of fission yeast all the telomeres become bundled at the spindle pole body and subsequently the nucleus undergoes a dynamic oscillation, resulting in elongated nuclear morphology known as "horsetail" nucleus. The pleckstrin homology domain is necessary for the cortical localisation of the Mcp5 protein during meiosis [PMID: 16585273].

GO terms

Biological Process

GO:0032065 cortical protein anchoring

Molecular Function

GO:0005543 phospholipid binding
GO:0005515 protein binding

Cellular Component

GO:0005938 cell cortex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam