Domain

Oestrogen-type nuclear receptor final C-terminal domain (IPR024736)

Short name: Oestrogen-typ_rcpt_final_C_dom

Domain relationships

None.

Description

This is the very C-terminal region of a subfamily of nuclear receptors that includes oestrogen receptors and other subfamily 3 group A members. The actual function of this region is not known, but the domain is absent from all the other types of nuclear receptors. Oestrogen receptors modulate AP-1-dependent transcription [PMID: 10751636] through two distinct mechanisms: via protein-protein interactions on DNA; and via non-genomic actions. The mechanism used depends on the cellular localisation of the receptor. In addition to the more extensively studied cross-talk on DNA, additional non-genomic actions might be very important in target tissues in which membrane-associated ERs are found. These non-genomic actions probably contribute to the overall physiological responses mediated by ligand-bound ERs [PMID: 15196329] and might possibly be mediated via this C-terminal domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam