Coagulation factor 5/8 (IPR024715)

Short name: Factor_5/8

Family relationships


Mammalian coagulation factors V (PIRSF500150) and VIII (PIRSF500250) play analogous roles as non-enzymatic cofactors in the activation of prothrombin and factor X, respectively. They are proteolytically activated by thrombin and inactivated by activated protein C (APC).

The structures of factor V and VIII have been determined [PMID: 15184653, PMID: 9834200]. The domain architecture of their precursor molecules can be represented as A1-A2-B-A3-C1-C2. The A domains are diverged versions of the multicopper oxidase domain (PF00394). The B domain is highly variable and is removed during activation to yield non-covalently-associated heavy and light chains; this domain in mammalian factor V contains multiple copies of a 9-residue repeat (see IPR009271). The C domains (PF00754) promote membrane binding.

GO terms

Biological Process

GO:0030168 platelet activation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.