Fascin, metazoans (IPR024703)

Short name: Fascin_metazoans

Overlapping homologous superfamilies


Family relationships


This family consists of several eukaryotic fascin proteins. Fascins are actin cross-linking proteins that function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles [PMID: 11948621]. In humans there are three fascin isoforms identified: fascin1-3. Fruit flies only have one fascin, also known as protein singed, which links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis [PMID: 24496629].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0051015 actin filament binding
GO:0030674 protein binding, bridging

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.