Domain

Heterogeneous nuclear ribonucleoprotein M, PY nuclear localisation signal (IPR024666)

Short name: HnRNP_M_PY-NLS

Domain relationships

None.

Description

Heterogeneous nuclear ribonucleoproteins (hnRNPs) bind directly to nascent RNA polymerase II transcripts and play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs [PMID: 8441656]. hnRNP M proteins are an abundant group of hnRNPs that have been shown to bind avidly to poly(G) and poly(U) RNA homopolymers [PMID: 8441656]. hnRNP M family members are able to induce exon skipping and promote exon inclusion, suggesting that the proteins may broadly contribute to the fidelity of splice site recognition and alternative splicing regulation [PMID: 17959601].

This entry represents the N-terminal PY nuclear localisation signal of heterogeneous nuclear ribonucleoprotein M [PMID: 17435768].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam