Domain

Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain (IPR024641)

Short name: HRS_helical

Domain relationships

None.

Description

This domain comprises the helical region of hepatocyte growth factor-regulated tyrosine kinase substrate (HRS). It is approximately 100 amino acids in length.

Hrs, together with signal transducing adaptor molecule (STAM), forms the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degradation [PMID: 19278655].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam