Domain

DNA polymerase epsilon subunit B, N-terminal (IPR024639)

Short name: DNA_pol_e_bsu_N

Domain relationships

None.

Description

This domain is found in the N-terminal of DNA polymerase epsilon subunit B proteins. It contains a single completely conserved phenylalanine residue that may be functionally important. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet.

DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. The N-terminal domain has close structural relation to AAA+ protein C-terminal domains [PMID: 18676977].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam