Domain

Gonadotropin hormone receptor, transmembrane domain (IPR024635)

Short name: GnHR_TM

Domain relationships

None.

Description

This domain represents the transmembrane region of follicular stimulating hormone and luteinizing hormone receptors- the two major gonadotropin hormone receptors. This domain is found in eukaryotes, and is approximately 70 amino acids in length. There are two completely conserved C residues that may be functionally important. The transmembrane region is conserved between the two different receptors, while the extracellular ligand binding domains are less well conserved [PMID: 18248232]. The follicular stimulating hormone and luteinizing hormone receptors are G protein-coupled receptors involved in development and maturation of germ cells in both fecund genders.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam