V(D)J recombination-activating protein 1 (IPR024627)

Short name: RAG1

Overlapping homologous superfamilies


Family relationships



The development of B and T cells depends on the rearrangement of variable (V), diversity (D), and joining (J) gene segments to produce mature Ig and T cell receptor coding regions. This rearrangement process, known as V(D)J recombination is initiated by a complex consisting of multi-domain proteins RAG1 and RAG2. The RAG proteins catalyse DNA cleavage in the first phase of the reaction using a recombination signal sequence (RSS) that flanks V, D and J segments [PMID: 9228952, PMID: 14671314, PMID: 22796426].

Recombination activating protein 1 (RAG1) is the catalytic component of the RAG complex [PMID: 19621044]. RAG1 contains a RING finger domain that can act as a ubiquitin ligase (E3), and can promote its own ubiquitylation and targets both karyopherin alpha 1 (KPNA1) and histone 3 (H3) [PMID: 19118899, PMID: 21256161].

Many of the proteins recognised by this entry are fragments.

GO terms

Biological Process

GO:0033151 V(D)J recombination

Molecular Function

GO:0004519 endonuclease activity
GO:0043565 sequence-specific DNA binding
GO:0061630 ubiquitin protein ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.