Domain

Inhibitor of growth protein, N-terminal histone-binding (IPR024610)

Short name: ING_N_histone_binding

Domain relationships

None.

Description

Histones undergo numerous post-translational modifications, including acetylation and methylation, at residues which are then probable docking sites for various chromatin remodelling complexes. Inhibitor of growth proteins (INGs) specifically bind to residues that have been thus modified. INGs carry a well-characterised C-terminal PHD-type zinc-finger domain, binding with lysine 4-tri-methylated histone H3 (H3K4me3), as well as this N-terminal domain that binds unmodified H3 tails. Although these two regions can bind histones independently, together they increase the apparent association of the ING for the H3 tail.

This entry represents the N-terminal histone binding domain found in inhibitor proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART