Family

Protein of unknown function DUF3827 (IPR024606)

Short name: DUF3827

Family relationships

None.

Description

The function of the proteins in this entry is not currently known, but one of the human proteins (Q9HCM3) has been implicated in pilocytic astrocytomas [PMID: 18974108, PMID: 19363522, PMID: 19937730]. In the majority of cases of pilocytic astrocytomas a tandem duplication produces an in-frame fusion of the gene encoding this protein and the BRAF oncogene. The resulting fusion protein has constitutive BRAF kinase activity and is capable of transforming cells.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam