CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 (IPR024557)

Short name: CCR4-Not_Not1su_DUF3819

Overlapping homologous superfamilies


Domain relationships



The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1 to Not5), Caf1, Caf40, Caf130 and Ccr4 [PMID: 10637334]. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress [PMID: 12957374]. Caf1 and Ccr4, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1, a putative RNA helicase thought to be a component of the decapping complex [PMID: 11696541]. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [PMID: 18430587].

This entry represents a domain of unknown function found in the Not1 subunit of the CCR4-Not complex.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.