Copper type II ascorbate-dependent monooxygenase, C-terminal (IPR024548)

Short name: Cu2_monoox_C

Overlapping homologous superfamilies

Domain relationships



Copper type II, ascorbate-dependent monooxygenases [PMID: 2792366] are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, dopamine-beta-monooxygenase (EC: and peptidyl-glycine alpha-amidating monooxygenase (EC: There are a few regions of sequence similarities between these two enzymes, two of these regions contain clusters of conserved histidine residues which are most probably involved in binding copper.

This entry represents the C-terminal domain of the enzyme which, like the N terminus has a PNGase F-like fold.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.