Domain

Histidyl tRNA synthetase-related domain (IPR024435)

Short name: HisRS-related_dom

Domain relationships

None.

Description

This entry represents the histidyl-tRNA synthetase-related (HisRS-related) domain, found largely in Gcn2 protein kinases [PMID: 1739968]. In yeast, Gcn2 phosphorylates the alpha subunit of eukaryotic initiation factor-2 (eIF-2) when the cells face the starvation for amino acids. The HisRS-related domain is required for activation of Gcn2 kinase function [PMID: 8798780, PMID: 10655230].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam