Family

SARS coronavirus, Orf3/3a (IPR024407)

Short name: SARS_coronavirus_Orf3/3a

Family relationships

None.

Description

This family of SARS coronavirus proteins includes Orf3/3a, which form homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. They have also been shown to up-regulate expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells [PMID: 16014971, PMID: 16474139, PMID: 16894145].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
Pfam