WYL domain containing protein (IPR024401)

Short name: WYL_prot

Overlapping homologous superfamilies


Family relationships



This entry represents a group of WYL domain containing proteins. WYL is named for three conserved amino acids found in a subset of domains of this superfamily. These residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine [PMID: 24817877], which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system [PMID: 24817877].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.