tRNA-splicing endonuclease, subunit Sen54 (IPR024337)

Short name: tRNA_splic_suSen54

Overlapping homologous superfamilies


Family relationships



tRNA-splicing endonucleases (EC: catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [PMID: 9321408, PMID: 9200603]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryotic tRNA-splicing endonucleases are heterotetrameric while the archaeal endonucleases can be split into homodimeric and homotetrameric subgroups.

Sen54 is a non-catalytic subunit of the tRNA-splicing endonuclease complex. Defects in human Sen54 are a cause of pontocerebellar hypoplasia type 4 [PMID: 18711368].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.