Domain

Suppressor of fused C-terminal (IPR024314)

Short name: SUFU_C

Domain relationships

None.

Description

This entry represents a domain found in the C-terminal of eukaryotic suppressor of fused (Sufu) proteins; it is not present in bacterial homologues.

Sufu is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding to these proteins and preventing their translocation to the nucleus. The Sufu C-terminal domain binds to the N-terminal of Gli/Ci, while the N-terminal of Sufu binds to the C-terminal of Gli/Ci. This dual binding mechanism is likely to be an evolutionary advancement in this signalling cascade, which is not present in bacterial homologues [PMID: 15367681].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam