Family

NUT family (IPR024310)

Short name: NUT

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The gene encoding Nuclear Testis (NUT) protein is found fused to BRD3 or BRD4 genes in some aggressive types of carcinoma due to chromosomal translocations [PMID: 12543779, PMID: 17934517]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [PMID: 12543779, PMID: 17934517]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein function.

NUT has a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS), both located towards the C-terminal end of the protein [PMID: 12543779, PMID: 17934517]. A fused NUT-GFP protein has shown either cytoplasmic or nuclear localisation, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B, an inhibitor of CRM1-dependent nuclear export, has been shown to result in re-distribution of NUT-GFP to the nucleus [PMID: 9323133, PMID: 9311922].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER