NUT family (IPR024310)

Short name: NUT

Family relationships



The gene encoding Nuclear Testis (NUT) protein is found fused to BRD3 or BRD4 genes in some aggressive types of carcinoma due to chromosomal translocations [PMID: 12543779, PMID: 17934517]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [PMID: 12543779, PMID: 17934517]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein function.

NUT has a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS), both located towards the C-terminal end of the protein [PMID: 12543779, PMID: 17934517]. A fused NUT-GFP protein has shown either cytoplasmic or nuclear localisation, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B, an inhibitor of CRM1-dependent nuclear export, has been shown to result in re-distribution of NUT-GFP to the nucleus [PMID: 9323133, PMID: 9311922].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.