Natural killer cell receptor 2B4 (IPR024304)

Short name: NK_rcpt_2B4

Overlapping homologous superfamilies


Family relationships



2B4 is a transmembrane receptor which is expressed primarily on natural killer (NK) cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells [PMID: 15850375]. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function [PMID: 15850375].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0038023 signaling receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.