Natural killer cell receptor 2B4, immunoglobulin domain (IPR024303)

Short name: NK_rcpt_2B4_Ig_dom

Overlapping homologous superfamilies

Domain relationships



2B4 is a transmembrane receptor which is expressed primarily on natural killer (NK) cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells [PMID: 15850375]. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function [PMID: 15850375].

This entry represents the 2B4 immunoglobulin domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.