SusD-like (IPR024302)

Short name: SusD-like

Overlapping homologous superfamilies

Family relationships



Mammalian distal gut bacteria have an expanded capacity to utilise glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.

This entry represents a family of SusD-like proteins, one member of which, BT1043 (Q8A8X4), is an outer membrane lipoprotein from B. thetaiotaomicron that is involved in host glycan metabolism [PMID: 19191477]. The structures of this and other SusD-homologues in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.