Urocortin II/III (IPR024270)

Short name: Urocortin_II/III

Overlapping homologous superfamilies


Family relationships


This entry represents urocortin II and III, which are members of the corticotropin-releasing factor (CRF) family of neuropeptides. Urocortin II and III are secreted peptides and bind with high affinity to CRF receptors 2-alpha and 2-beta. They are involved in the suppression of food intake, the delay of gastric emptying, and may represent endogenous ligands for maintaining homeostasis after stress. Their backbone is mainly alpha-helical, but contains a helix-loop-helix motif [PMID: 18052377].

GO terms

Biological Process

GO:0007586 digestion

Molecular Function

GO:0051431 corticotropin-releasing hormone receptor 2 binding

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.